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Synfacts 2007(8): 0887-0887
DOI: 10.1055/s-2007-968813
DOI: 10.1055/s-2007-968813
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
3-Methyl-1-p-Tolyltriazene: A Novel Methyl Esterification Agent
Y. Miura, Y. Shinohara, J.-i. Furukawa, N. Nagahori, S.-i. Nishimura*
Hokkaido University, Sapporo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
24. Juli 2007 (online)
Significance
A rapid and quantitative ethyl esterification of oligosaccharides with sialic acid residue was achieved with 3-ethyl-1-p-tolyltriazene in solution as well as on solid supports. A sialylated saccharide anchored onto a polymer support was treated with 3-methyl-1-p-tolyltriazene in DMSO-acetonitrile to afford the methyl ester derivative, which was isolated without any chromatographical post-treatments. The solution-phase esterification was also demonstrated.