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Synfacts 2007(9): 0972-0972  
DOI: 10.1055/s-2007-968824
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Diarylketones from Arylboronic Acids and Aldehydes

Contributor(s): Paul Knochel, Andrei Gavryushin
G. Mora, S. Darses*, J.-P. Genet*
Ecole Nationale Supérieure de Chimie de Paris, France
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Publication History

Publication Date:
23 August 2007 (online)

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Significance

The benzophenone unit is encountered in various biologically relevant molecules. This reaction offers a simple and versatile process for the preparation of functionalized benzophenones, starting from aryl or hetaryl aldehydes and arylboronic acids. It avoids the regioselectivity and functional group compatibility problems, associated with the conventional Friedel-Crafts reaction or the application of highly reactive organometallic species.