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Synthesis of (±)-Indatraline
L. F. Silva, Jr.*, F. A. Siqueria, E. C. Pedrozo, F. Y. M. Vieira, A. C. Doriguetto
Universidade de São Paulo and Universidade Federal de Alfenas, Brazil
23 August 2007 (online)
(±)-Indatraline can be used to prevent chronic stimulant abuse by substituting the methamphetamine-like stimulants. The salient feature of the synthesis is an iodine(III)-mediated diastereoselective ring contraction of 1,2-dihydronaphthalene A to form the indane derivative D.