Synfacts 2007(9): 0894-0894  
DOI: 10.1055/s-2007-968838
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of FR901512

Contributor(s): Philip Kocienski
M. Inoue, M. Nakada*
Waseda University, Tokyo, Japan
Further Information

Publication History

Publication Date:
23 August 2007 (online)


FR901512 is a potent HMG-CoA reductase inhibitor (IC50 = 1.0 nM). It is the first naturally occurring statin possessing a tetralin core. The synthesis depicted twice exploits efficient catalytic asymmetric Nozaki-Hiyama allylations.