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Chiral Tertiary Alcohols by Addition of Organoaluminum Compounds
C.-A. Chen, K.-H. Wu, H.-M. Gau*
National Chung Hsing University, Taichung, Taiwan
23 August 2007 (online)
Synthesizing chiral tertiary alcohols derived from the corresponding ketones by enantioselective addition of carbon nucleophiles is still a challenging task. The authors present a mild enantioselective addition of aryl groups to a variety of aromatic ketones and generate the corresponding tertiary alcohols in high yields and ee. Previous results of this group are described in K.-H. Wu, H.-M. Gau J. Am. Chem. Soc. 2006, 128, 14808.