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Highly Regioselective Hydrative Cyclization of Trialkynes
H.-K. Chang, S. Datta, A. Das, A. Odedra, R.-S. Liu*
National Tsing-Hua University, Hsinchu, Taiwan
23 August 2007 (online)
Described in this report is a novel type of platinum-catalyzed cyclization of alkynes that proceeds highly regioselectively to give bicyclic spiro ketones. The importance of this report is the observation of highly selective hydration of the PhC≡CPh bond over PhC≡CMe, which has not been reported so far and is contrary to the ones reported.