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Highly Stereoselective Cycloisomerization of Alkoxyalkynes
J. Barluenga*, L. Riesgo, R. Vicente, L. A. López, M. Tomás
Universidad de Oviedo, Spain
23 August 2007 (online)
A novel mode of reactivity in metal-catalyzed cycloisomerization of propargylic esters is described. The crucial result shown in this report is the ability of a copper catalyst, which is rarely used in these types of reaction, to yield rearranged products smoothly. This is one of the first examples where alkoxyalkyne substrates were used.