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Synfacts 2007(9): 0941-0941
DOI: 10.1055/s-2007-968866
DOI: 10.1055/s-2007-968866
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
syn-1,2-Amino Alcohols via Allylic C-H Amination
K. J. Fraunhoffer, M. C. White*
University of Illinois, Urbana, USA
Further Information
Publication History
Publication Date:
23 August 2007 (online)
Significance
Amino alcohols are unquestionably important compounds in biologically relevant settings. This paper describes a new approach for the diastereoselective synthesis of these compounds starting from a homoallylic alcohol derivative. Palladium catalyzed allylic C-H amination provides these important molecules in an expedient and selective manner.