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Alkylative Aldol Reaction: Multicomponent Assembly of δ-Lactones
K. Oisaki, D. Zhao, M. Kanai, M. Shibasaki*
The University of Tokyo, Japan
23 August 2007 (online)
This paper is a significant contribution to the emerging field of multicomponent reactions. Three distinct bond-forming events take place in a single step to give δ-lactones containing an asymmetric quaternary carbon stereocenter. The asymmetric aldol reaction to ketones is the key enantioselective step in this protocol.