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Hydrogenation of α-Hydroxy Ketones Catalyzed by MsDPEN-CP*Ir(III)
T. Ohkuma*, N. Utsumi, M. Watanabe, K. Tsutsumi, N. Arai, K. Murata
Hokkaido University, Sapporo and Kanto Chemical CO., Inc., Saitama, Japan
23 August 2007 (online)
Aromatic α-hydroxy ketones are hydrogenated in very high yields with very high enantioselectivity. This class of ketones has not been successfully hydrogenated prior to this report. The low catalyst loading (S/C = 6000:1) is quite a nice feature. The ligand structure of the Ir catalyst was found to be crucial for reactivity and selectivity.