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Tetrasubstituted Carbons: Pd-Catalyzed 1,3-Chirality Transfer
N. Kawai*, J.-M. Lagrange, J. Uenishi*
Kyoto Pharmaceutical University, Japan
23 August 2007 (online)
This paper describes a palladium-catalyzed cyclization reaction to generate chiral tetrahydropyran systems. A 2,2,6-tetrahydropyran as well as a spiropyran is generated with complete transfer of chirality. These classes of pyran molecules are highly prevalent in natural products and are biologically important targets.