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Synfacts 2007(9): 0947-0947  
DOI: 10.1055/s-2007-968869
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Tetrasubstituted Carbons: Pd-Catalyzed 1,3-Chirality Transfer

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
N. Kawai*, J.-M. Lagrange, J. Uenishi*
Kyoto Pharmaceutical University, Japan
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Publikationsdatum:
23. August 2007 (online)

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Significance

This paper describes a palladium-catalyzed cyclization reaction to generate chiral tetrahydropyran systems. A 2,2,6-tetrahydropyran as well as a spiropyran is generated with complete transfer of chirality. These classes of pyran molecules are highly prevalent in natural products and are biologically important targets.