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Organocatalytic Asymmetric Transfer Hydrogenation of β,β-Disubstituted Nitroolefins
N. J. A. Martin, L. Ozores, B. List*
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
23 August 2007 (online)
The first organocatalytic enantioselective transfer hydrogenation of nitroolefins using a Jacobsen-type thiourea catalyst is reported. A broad substrate scope of this reaction is shown. With 5-10 mol% of catalyst good yields (82% to >99%) and high enantioselectivities (er: up to 98:2) are obtained. Aliphatic, aromatic, and sterically hindered substituents R1 in β-position are well tolerated.