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Thiourea-Catalyzed Transfer Hydrogenation of Aldimines
Z. Zhang, P. R. Schreiner*
Justus-Liebig-Universität Giessen, Germany
23 August 2007 (online)
The authors report a practical method for the reductive amination of aldehydes and reduction of aldimines using thiourea catalyst 1 and also question some of the published results on the reductive amination of aldehydes and ketones. They found that thiourea catalyst 2 is inefficient for the reductive amination of benzaldehyde but thiourea catalyst 1 smoothly gave the product in 86% yield. In addition, with 1 mol% of catalyst 1, good to excellent yields (80-93%) were obtained for the reduction of different preformed aromatic and aliphatic aldimines.