Synfacts 2007(9): 0936-0936  
DOI: 10.1055/s-2007-968888
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Cavitand Sensors for DMMP Using Surface Plasmon Resonance (SPR)

Contributor(s): Timothy M. Swager, Ryan M. Moslin
S. M. Daly*, M. Grassi, D. K. Shenoy, F. Ugozzoli, E. Dalcanale*
Center for Bio/Molecular Science and Engineering, Washington, USA and Università di Parma, Italy
Further Information

Publication History

Publication Date:
23 August 2007 (online)

Significance

The synthesis of resorcinarene-based cavitands containing a single carboxylic acid group, pointed into or out of the cavity, is reported. As a result of the hydrophobic rim of the cavity the compounds, C5-COOHout and C5-COOHin, show high selectivity for detection of dimethylmethylphosphonate (DMMP) over water as measured by SPR spectroscopy. Both compounds are superior to a fluoropolyol layer in terms of sensitivity and selectivity, but C5-COOHin shows a reduced response to water vapors due to the location of the carboxylic acid binding group within the hydrophobic core.