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Synfacts 2007(9): 0999-0999
DOI: 10.1055/s-2007-968920
DOI: 10.1055/s-2007-968920
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Self-Purified Solid-Phase Synthesis of Peptide Thioesters
F. Mende, O. Seitz*
Humboldt-Universität zu Berlin, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. August 2007 (online)
Significance
A cyclization-thiolysis sequence was developed for the synthesis of peptide thioesters with self-purification. Thus, linker 1 was installed to polymer-supported peptide sulfone amides 2 to give 3, which were converted into 6 via macrocyclization. Thiolysis of 6 gave non-cyclic truncation byproducts that were hence washed away. Only the full-length peptide thioesters 8 were detached from 7 as pure forms in the final step.