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Synthesis of Macrocycles by Cyclocarbonylation with Palladium Dendrimers
S.-M. Lu, H. Alper*
University of Ottawa, Canada
23 August 2007 (online)
The first intramolecular cyclocarbonylation reaction with recyclable Pd-complexed dendrimers on silica gel was developed to form oxygen-, nitrogen-, or sulfur-containing large ring-fused heterocycles. Thus, the reaction of 1 with G1-Pd (0.15 mol% Pd) was performed in the presence of DIPEA in toluene under 100 psi CO atmosphere to give macrocyclic compounds 2 in 70-92% yield (12-18 membered rings; 27 examples). The catalyst was reused seven times without loss of catalytic activity.