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A Magnetic-Nanoparticle-Supported DMAP Catalyst
C. Ó Dálaigh, S. A. Corr, Y. Gun’ko*, S. J. Connon*
University of Dublin, Ireland
23 August 2007 (online)
The first magnetic-nanoparticle-supported DMAP was developed as a heterogeneous organocatalyst. The supported DMAP 2 was prepared by a concise route starting from magnetite (Fe3O4). Catalyst 2 was applied to acylation of alcohol 3 and glucose 7 with acetic anhydride, bishydroalkoxylation of alkyne 5, and Boc protection of indole 9 to give the corresponding products in high yield.