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Synfacts 2007(10): 1085-1085  
DOI: 10.1055/s-2007-968928
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Halogen-Promoted Catalytic Friedel-Crafts Alkylation with Alkenes

Contributor(s): Paul Knochel, Andrei Gavryushin
S. Hajra*, B. Maji, S. Bar
Indian Institute of Technology, Kharagpur, India
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Publikationsverlauf

Publikationsdatum:
07. November 2007 (online)

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Significance

The Friedel-Crafts alkylation is one of the most common C-C bond-forming reactions. This is the first report concerning the Friedel-Crafts alkylation of arenes, using halonium ions as intermediates. This reaction gives a simple synthetic way to 1,1-diaryl-2-haloalkanes and α,α-diaryl-β-haloesters and -ketones. Substituted styrenes, cinnamic esters and halcones are suitable intermediates.