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Synfacts 2007(10): 1058-1058  
DOI: 10.1055/s-2007-983854
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Pd(II)/Pd(IV)-Mediated Aminooxygenation of Alkenes

Contributor(s): Mark Lautens, Michael Langer
L. V. Desai, M. S. Sanford*
University of Michigan, Ann Arbor, USA
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

Catalytic pathways involving highly oxidized transition metals can often yield products complementary to those obtained with traditional redox couples. The authors explored a Pd(II)/Pd(IV)-catalyzed aminooxygenation of alkenes to yield trans-substituted tetrahydrofurans. The mechanism of the reaction is investigated. For previous work on Pd(IV), see: K. L. Hull et al. J. Am. Chem. Soc. 2006, 128, 7134.