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Synfacts 2007(11): 1115-1115  
DOI: 10.1055/s-2007-991212
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Asperazine

Contributor(s): Philip Kocienski
S. P. Govek, L. E. Overman*
University of California, Irvine, USA
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Publikationsdatum:
23. Oktober 2007 (online)

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Significance

Asperazine was isolated from a salt-water culture of Aspergillus niger. Its putative anticancer activity was disproved by the synthesis depicted, which features a Stille coupling followed by an intramolecular Heck cyclization to install the highly congested quaternary center in B.