Synfacts 2007(11): 1218-1218  
DOI: 10.1055/s-2007-991221
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Suzuki Cross-Coupling Reaction with Chitosan-Supported Palladium(0) Catalyst in Water

Contributor(s): Yasuhiro Uozumi, Yutaka Matsuura
S.-S. Yi, D.-H. Lee, E. Sin, Y.-S. Lee*
Seoul National University, Korea
Further Information

Publication History

Publication Date:
23 October 2007 (online)

Significance

The reaction of chitosan beads with Pd(OAc)2 gave chitosan-supported palladium(II). Then the palladium(II) in the chitosan beads was converted into palladium(0) (polymeric Pd 1) by treatment with hydrazine hydrate. The chitosan-palladium polymeric composite 1 was crosslinked by diglycidyl ether polyethylene glycol to yield cata­lyst 2. The Suzuki cross-coupling reaction of various aryl halides and aryl boronic acids was carried out with catalyst 2 in water under micro­wave-irradiation conditions to afford the corresponding biaryl compounds in 14-98% yield. The presence of tetrabutylammonium bromide accelerated the reaction.