RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
PDF herunterladen
Synfacts 2007(11): 1191-1191
DOI: 10.1055/s-2007-991235
DOI: 10.1055/s-2007-991235
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New YorkSynthesis of Acetophenones via Regioselective Arylation of Vinyl Ethers
R. K. Arvela, S. Pasquini, M. Larhed*
Uppsala University, Sweden and Università degli Studi di Siena, Italy
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Oktober 2007 (online)
Significance
This interesting and elegant protocol for the Heck arylation reaction in water is also a quite synthetically useful method for the mild preparation of acetophenones from aryl halides. The reaction is usually completely regioselective and affords high yields of products after the hydrolysis. Functional groups and ortho-substituents in substrates are well tolerated. This method can also be applied to some aryl chlorides and heteroarenes.