Synfacts 2007(11): 1190-1190  
DOI: 10.1055/s-2007-991236
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Pd/C-Catalyzed Transfer Hydrogenation with Et3SiH

Contributor(s): Paul Knochel, Andrei Gavryushin
P. K. Mandal, J. S. McMurray*
The University of Texas M. D. Anderson Cancer Center, Houston, USA
Further Information

Publication History

Publication Date:
23 October 2007 (online)

Significance

The catalytic transfer of hydrogen is a useful and safe alternative to conventional catalytic hydrogenation with gaseous H2. The reported procedure represents a very convenient, simple and versatile protocol for the reduction of C-C multiple bonds, imines, nitro groups as well as removal of benzylic and allylic protecting groups under mild conditions. The yields are very high, even for complex substrates, and many other functionalities are tolerant to the mild conditions used.