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Synfacts 2007(11): 1180-1180  
DOI: 10.1055/s-2007-991249
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Domino Hydroformylation/Organocatalytic Aldol Reaction

Contributor(s): Mark Lautens, Praew Thansandote
O. Abillard, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany
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Publikationsdatum:
23. Oktober 2007 (online)

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Significance

The first domino hydroformylation-enantioselective organocatalytic cross-aldol sequence is described between simple alkenes and aldehydes. The corresponding products are useful polypropionate building blocks and can be obtained in excellent diastereoselectivities and enantioselectivities.