Stereoselective Synthesis of Substituted Isoxazolidines

Significance

The synthesis of isoxazolidines, which are often found in biologically relevant compounds, is usually achieved by 1,3-dipolar cyclo­addition. The authors report a diastereoselective palladium-mediated synthesis which gives easy access to currently unavailable isoxazolidine stereoisomers. A variety of heterocyclic ring systems can be synthesized which can potentially react further to yield highly functionalized five- and six-membered ring systems.