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Synthesis of Methyl Sarcophytoate
T. Ichige, Y. Okano, N. Kanoh, M. Nakata*
Keio University, Yokohama, Japan
22 November 2007 (online)
The synthesis of methyl sarcophytoate depicted features a Diels-Alder reaction between two cembranoid units (H and I) - the probable biogenetic route to the natural product. A major achievement was the discovery of conditions for the macrocyclization reaction (E→F).