Synfacts 2007(12): 1223-1223  
DOI: 10.1055/s-2007-991311
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Pyrrole-Based HMG-CoA Reductase Inhibitors

Contributor(s): Philip Kocienski, Indu Dager
J. A. Pfefferkorn et al.*
Pfizer Global Research and Development, Ann Arbor, USA
Further Information

Publication History

Publication Date:
22 November 2007 (online)


Hypercholesterolemia increases the risk of coronary heart disease and can be controlled by inhibiting the enzyme HMG-CoA reductase which blocks the rate-limiting step of cholesterol synthesis. An efficient second-generation synthesis of a pyrrole-based HMG-CoA reductase inhibitor I, which is a regioisomer of atorvastatin (Lipitor®), is reported here.