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Synthesis of Pyrrole-Based HMG-CoA Reductase Inhibitors
J. A. Pfefferkorn et al.*
Pfizer Global Research and Development, Ann Arbor, USA
22 November 2007 (online)
Hypercholesterolemia increases the risk of coronary heart disease and can be controlled by inhibiting the enzyme HMG-CoA reductase which blocks the rate-limiting step of cholesterol synthesis. An efficient second-generation synthesis of a pyrrole-based HMG-CoA reductase inhibitor I, which is a regioisomer of atorvastatin (Lipitor®), is reported here.