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Synfacts 2007(12): 1234-1234  
DOI: 10.1055/s-2007-991316
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Archazolid B

Contributor(s): Philip Kocienski, Zofia Komsta
P. A. Roethle, I. T. Chen, D. Trauner*
University of California, Berkeley, USA
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

(-)-Archazolid B, isolated from the myxobacterium Archangium gephyra, selectively inhibits mammalian V-ATPases. The synthesis features three very different Ru-catalyzed reactions: (1) Kita esterification, (2) Trost-Alder-ene reaction, and (3) relay ring-closing metathesis.