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Copper-Catalyzed Sulfonylation of Arylboronic Acids
A. Kar, I. A. Sayyed, W. F. Lo, H. M. Kaiser, M. Beller, M. K. Tse*
Leibniz-Institut für Katalyse e.V. and der Universität rostock and Universität Rostock, Germany
22 November 2007 (online)
Aryl sulfones are widely present among modern drugs and various biologically active compounds. Herein, the authors report a catalytic version of Cu-promoted sulfonylation of boronic acids with alkyl- and arylsulfinate salts. This method tolerates most functional groups, including free hydroxyl, and can be applied as well to heterocycles and alkenylboronic acids. The broad range of suitable substrates makes this protocol especially attractive for modular and combinatorial synthesis.