Synfacts 2007(12): 1304-1304  
DOI: 10.1055/s-2007-991324
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed α-Arylation of Malonates

Contributor(s): Paul Knochel, Andrei Gavryushin
S. F. Yip, H. Y. Cheung, Z. Zhou, F. Y. Kwong*
The Hong Kong Polytechnic University, Kowloon, Hong Kong, P. R. of China
Further Information

Publication History

Publication Date:
22 November 2007 (online)


This publication describes a simple and inexpensive method for the preparation of α-aryl malonates from the corresponding aryl and heteroaryl iodides. The reactions are conveniently performed at room temperature. Electron-rich and electron-poor aryl iodides react equally well. While some other protocols applying copper catalysis for this reaction have already been published, this is the most practical one for aryl iodides published up to date.