Synfacts 2007(12): 1305-1305  
DOI: 10.1055/s-2007-991327
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Amidation with Chloramine T

Contributor(s): Paul Knochel, Andrei Gavryushin
R. Bhuyan, K. M. Nicholas*
University of Oklahoma, Norman, USA
Further Information

Publication History

Publication Date:
22 November 2007 (online)


The functionalization of hydrocarbons via a direct C-H amination is a highly attractive synthetic transformation. The method reported herein is remarkably simple and uses only inexpensive, commercially available reagents and catalysts. Good yields of products are obtained from benzylic substrates as well as from some cyclic ethers. Alkenes undergo amidochlorination along with allylic amidation. The products can be reductively deprotected to the corresponding benzyl­amines.