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Use of Fluorinated Alcohols in Enantioselective Hydrogenation
N. V. Dubrovina*, I. A. Shuklov, M.-N. Birkholz, D. Michalik, R. Paciello, A. Börner
Leibniz-Institut für Katalyse an der Universität Rostock e. V., Institut für Chemie der Universität Rostock and BASF AG, Ludwigshafen, Germany
22 November 2007 (online)
Self-assembling phosphanyl-pyridone ligands have been used in several hydrogenation reactions. Difficulties obtaining both good yields and selectivities are still present. In this report, those difficulties are eliminated by use of fluorinated alcohols which enable formation of hydrogen bonding between ligand molecules - the key feature responsible for the stereoselective outcome of the reaction.