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Synfacts 2007(12): 1285-1285  
DOI: 10.1055/s-2007-991349
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

C-S Bond Formation by Iron-Catalyzed Michael Addition of Thiols

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
M. Kawatsura*, Y. Komatsu, M. Yamamoto, S. Hayase, T. Itoh*
Tottori University, Japan
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

The authors describe a carbon-­sulfur bond-forming Michael addition. Chiral sulfur-containing compounds are useful for both organic and medicinal chemistry and access to these products remains an important task. The use of an iron-centered catalyst makes this a useful protocol due to the environmentally friendly nature of iron. Good to high enantioselectivities are obtained in this reaction.