Subscribe to RSS
New Ligands for Rhodium-Catalyzed Asymmetric Hydrogenation of Olefins
L. Eberhardt, D. Armspach*, D. Matt*, B. Oswald, L. Toupet
Université des Rennes, Institut de Chimie and Université Louis Pasteur, Strasbourg, France and Genzyme Pharmaceuticals, Liestal, Switzerland
22 November 2007 (online)
The present work illustrates that enantiopure BINOL-derived diphosphoramidite ligands with hydrazine spacers are good ligands for the rhodium-catalyzed hydrogenation of 2-acetylamino-3-arylpropenoic methyl esters. The substituents on the two hydrazine nitrogens have a large influence on the enantioselectivity of the reaction, with bulky symmetrical groups leading to the highest ee values.