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Regioselective Synthesis of sec- and tert-Allylamines
A. M. Johns, Z. Liu, J. F. Hartwig*
University of Illinois Urbana-Champaign and Yale University, New Haven, USA
22 November 2007 (online)
Control of the regioselectivity in palladium-catalyzed allylic substitution is still challenging. The authors report on the addition of hydroxylamine and hydrazone derivatives to 1,3-dienes or unsymmetrical allyl systems which yield the branched isomers predominantly or exclusively. The products of the reaction can be converted into secondary or tertiary carbinamines.