Copper-Catalyzed α-Enolate Arylation Route to 2,3-Disubstituted Indoles

doi:10.1055/s-2007-991406

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml

Teilen / Bookmarken

Facebook Linkedin Weibo

PDF herunterladen

Synfacts 2007(12): 1239-1239
DOI: 10.1055/s-2007-991406

Synthesis of Heterocycles

Copper-Catalyzed α-Enolate Arylation Route to 2,3-Disubstituted Indoles

Contributor(s): Victor Snieckus, Yigang Zhao
S. Tanimori*, H. Ura, M. Kirihata
Osaka Prefecture University, Japan

Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. November 2007 (online)

Lizenzen und Reprints

Significance

A one-step synthesis of 2,3-disubstituted indoles via Cu-catalyzed α-arylation-cyclization of 2-iodoaniline with β-keto esters is described. This reaction proceeds smoothly under mild conditions in modest to excellent yields. 2-Aryl-, -heteroaryl-, and -monoterpenoid-substituted indoles were prepared. However, the scope and limitations of the iodoaniline coupling partner were not well investigated.