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A Modular Synthesis of Isoxazoles
J. P. Waldo, R. C. Larock*
Iowa State University, ames, USA
23 January 2008 (online)
A variety of isoxazoles have been synthesized in high yields via an electrophilic cyclization reaction. The iodine handle that is installed as part of the electrocylization is used in a subsequent Suzuki-Miyaura coupling reaction that yields the highly potent COX-2 inhibitor valdecoxib in 74% yield.