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Rhodium-Catalyzed Cycloisomerization of 1,6-Enynes
F. Liu, Q. Liu, M. He, X. Zhang*, A. Lei
Wuhan University, P. R. of China and The Pennsylvania State University, University Park, USA
23 January 2008 (online)
The authors have previously reported the use of their second-generation [Rh(cod)Cl]2-BINAP-AgSbF6 system in cycloisomerization reactions to form lactones, lactams, and tetrahydrofurans (J. Am. Chem. Soc. 2002, 124, 8198). In the present work they report the application of this system to the cycloisomerization of 1,6-enynes to give functionalized cyclopentanes and cyclopentanones in high yields and excellent enantiomeric excesses. Furthermore, only 1,4-dienes were observed as products.