Subscribe to RSS
Samarium(II) Iodide Catalyzed One-Pot Aza-Diels-Alder Reactions
Z. Zhou, F. Xu*, X. Han, J. Zhou, Q. Shen*
Suzhou University, P. R. of China
23 January 2008 (online)
The authors describe a three-component aza-Diels-Alder reaction that is catalyzed by samarium(II) iodide. Interestingly, the cis/trans isomer issue can be controlled by the reaction conditions. When the reaction is conducted in organic solvents, the trans isomer is favored. Under solvent-less conditions, the cis isomer predominates. Higher temperatures were also found to give high yields of the trans product, while lower temperatures increased the cis selectivity.