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Synthesis of P-Chiral Phosphine Ligands with Alkynyl Groups
T. Imamoto*, Y. Saitoh, A. Koide, T. Ogura, K. Yoshida
Chiba University, Japan
23 January 2008 (online)
Many years ago, Imamoto and co-workers discovered stable P-B complexes and used them to synthesize various chiral phosphines. Here he reports the synthesis of P-chiral phosphines containing alkynyl groups. The procedure offers a variety of chiral phosphines, many of which succeeded as ligands in asymmetric reactions such as hydrogenation, conjugate addition and an alkylative ring-opening reaction.