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Synfacts 2008(2): 0186-0186
DOI: 10.1055/s-2007-992479
DOI: 10.1055/s-2007-992479
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Carboannulation of o-Bromobenzyl Zinc Bromide with Alkenes and Alkynes
R. Deng, L. Sun*, Z. Li
Tianjin University, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Januar 2008 (online)
Significance
Indene and indane scaffolds are present in many biologically active compounds. Indene is also an important motif in modern catalysts for selective olefin polymerization. This reaction gives an operationally simple one-step method for the regioselective preparation of indenes and indanes from readily available starting materials. The use of TMS alkynes, followed by the removal of the TMS group by CF3CO2H provides a general method for the preparation of both 1- and 2-substituted indenes from the same alkyne.