Synfacts 2008(2): 0122-0122  
DOI: 10.1055/s-2007-992502
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of ()-Frondosin B

Contributor(s): Philip Kocienski, Stewart Eccles
X. Li, T. V. Ovaska*
Connecticut College, New London, USA
Further Information

Publication History

Publication Date:
23 January 2008 (online)


Frondosin B exhibits anti-HIV, anti-inflammatory, and anti-tumor activity. The authors utilize a microwave-induced 5-exo-dig cyclization (AB) followed by in situ Claisen rearrangement (BC) to produce the seven-membered ring. This short synthesis of frondosin B was accomplished in 38% overall yield (7 steps).