Three-Component Coupling Reaction Using Silica-Immobilized CuI Catalyst

Signifance

The three-component coupling of aldehydes, amines, and alkynes by using silica-immobilized CuI catalyst was described. Silica-supported copper catalyst SiO ₂ -Py-CuI was prepared from 2-pyridylimine functionalized silica SiO ₂ -Py with CuI in acetonitrile (eq. 1). The three-component coupling reactions of aldehydes, amines, and alkynes were carried out in the presence of 5 mol% silica-immobilized CuI catalyst SiO ₂ -Py-CuI in ­acetonitrile at 90 °C to give the corresponding propargylamines in 54-93% yield (eq. 2).