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© 1999 by Thieme Medical Publishers, Inc.
Functional Residual Capacity and Pulmonary Mechanics in Premature Infants Receiving a 12-Day Dexamethasone Course
04 March 2008 (online)
The objective of this paper is to determine the effects of a 12-day dexamethasone course of the pulmonary function of preterm infants. The design consisted of a consecutive sample of eligible patients, before-after trial. The Regional referral center neonatal ICU was the setting. The patients were 13 preterm infants, 545-1315 g, requiring mechanical ventilation. The following was used: Intravenous dexamethasone for a 12-day tapering course beginning at 0.5 mglkg every 12 hr. Main outcome measures were as follows: Measurements of functional residual capacity (FRC), compliance, resistance, arterial blood gases and alveolar-arterial differences, level of ventilatory assistance, weight, length. All measures of pulmonary function demonstrated significant improvement by Day 12 of treatment. Most improvement occurred in the first 6 days of treatment, in association with increased lung volume.
Neonatal respiratory distress - steroid treatment - lung volume - bronchopulmonary dysplasia