Beckwith-Wiedemann Syndrome: Prenatal Ultrasound Diagnosis Using Standard Kidney to Abdominal Circumference Ratio

Howard Grundy; Sheila Walton; Jeanette Burlbaw; Stanley Shaffer; Alan McLeod; Carole Dannar

doi:10.1055/s-2007-999958

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 1985; 2(3): 236-239
DOI: 10.1055/s-2007-999958

ORIGINAL ARTICLE

Beckwith-Wiedemann Syndrome: Prenatal Ultrasound Diagnosis Using Standard Kidney to Abdominal Circumference Ratio

Howard Grundy¹ , Sheila Walton² , Jeanette Burlbaw² , Stanley Shaffer³ , Alan McLeod⁴ , Carole Dannar² Sr.

¹Director, Maternal Fetal Medicine, Fetal Diagnostic Unit, St. Luke's Perinatal Center; Associate Clinical Professor, University of Missouri, Kansas City, Missouri
²Fetal Diagnostic Unit, St. Luke's Perinatal Center, Kansas City, Missouri
³Neonatology Fellow, Children's Mercy Hospital, Kansas City, Missouri
⁴Department of Radiology, St. Luke's Hospital, Kansas City, Missouri

Abstract

ABSTRACT

Enlarged fetal kidneys are characteristic of more than one possible diagnosis. Though infantile polycystic kidney disease is probably the most well known entity and is associated with oligohydramnios, Beckwith-Wiedemann syndrome should be considered in the differential diagnosis especially if a normal or increased amount of amniotic fluid is present. The presence of an omphalocele with a normal karyotype should also arouse suspicion. This constellation of findings carries potential morbidity including macrosomia, fetal hypoglycemia, mental retardation, microcephaly, increased risk of subsequent neoplasia, and even neonatal death. Beckwith-Wiedemann syndrome may not be obvious in the newborn period.

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