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Synthesis of trans-2,6-Disubstituted Piperazines
B. M. Cochran, F. E. Michael*
University of Washington, Seattle, USA
19 March 2008 (online)
A short and operationally simple synthesis of enantiopure trans-2,6-substituted piperazines is reported with excellent yields and high diastereoselectivity. Cyclization precursors 1 are readily available from chiral amino alcohols and simple allylamines by an improved practical protocol. The strategy takes advantage of the numerous established methods to prepare chiral amino alcohols.