Synfacts 2008(4): 0380-0380  
DOI: 10.1055/s-2008-1042793
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ruthenium-Catalyzed Regio- and Enantioselective O-Allylation

Contributor(s): Mark Lautens, Praew Thansandote
K. Onitsuka*, H. Okuda, H. Sasai
Osaka University, Japan
Further Information

Publication History

Publication Date:
19 March 2008 (online)


A highly regio- and enantioselective O-allylation of phenols and alcohols is described using a planar-chiral cyclopentadienyl ruthenium complex. Allylation predominantly takes place at the more substituted allylic carbon, producing high branched/linear ratios.