Subscribe to RSS
Palladium-Catalyzed One-Pot Enantioselective Synthesis of Arylglycines
H. Dai, M. Yang, X. Lu*
Shanghai Institute of Organic Chemistry, P. R. of China
19 March 2008 (online)
A palladium-catalyzed one-pot enantioselective synthesis of arylglycines has been developed from ethyl glyoxylate, p-toluenesulfonyl isocyanate and arylboronic acids. A good scope of arylboronic acids can be used, including electron-withdrawing and electron-donating examples. The imino esters were prepared in situ by a [2+2] cycloaddition and were inspired by Holmes and co-workers (P. Hamley, A. B. Holmes, A. Kee, T. Ladduwahetty, D. F. Smith Synlett 1999, 29).