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Three-Component Couplings via Internal Redox
A. Herath, W. Li, J. Montgomery*
University of Michigan, Ann Arbor, USA
19 March 2008 (online)
Two nickel-catalyzed three-component couplings are introduced in this article: the coupling between enals, alkynes, and alcohols and the coupling between enones, alkynes, and aldehydes. The latter proceeds with good regioselectivities directly furnishing allylated 1,3-dicarbonyls. With this method, the laborious preparation of unsymetrically substituted 1,3-diketones and stereodefined allylic electrophiles can be elegantly circumvented.