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Synfacts 2008(4): 0374-0374  
DOI: 10.1055/s-2008-1042866
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rhodium-Catalyzed Enantioselective Direct Aldol Reaction

Contributor(s): Hisashi Yamamoto, Marina Naodovic
H. Inoue, M. Kikuchi, J.-I. Ito, H. Nishiyama*
Nagoya University, Japan
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

The rhodium-bis(oxazolinyl)phenyl complex is shown to effectively promote the direct aldol reaction yielding products in highly stereo­selective fashion. The authors suggest that ‘Phebox’-Rh catalyst incorporates both Lewis acidic and Brønstead basic sites which are responsible for activation of the carbonyl group and formation of the enolate moiety.