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Rhodium-Catalyzed Enantioselective Direct Aldol Reaction
H. Inoue, M. Kikuchi, J.-I. Ito, H. Nishiyama*
Nagoya University, Japan
19 March 2008 (online)
The rhodium-bis(oxazolinyl)phenyl complex is shown to effectively promote the direct aldol reaction yielding products in highly stereoselective fashion. The authors suggest that ‘Phebox’-Rh catalyst incorporates both Lewis acidic and Brønstead basic sites which are responsible for activation of the carbonyl group and formation of the enolate moiety.